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PRF injections for the under-eye area are a regenerative treatment used to improve dark circles, hollowness, fine lines, and crepey skin—without synthetic fillers. Also, it is a NATURAL aesthetic treatment because it uses your own stem cells and growth factors. The results from PRF provide a radiant and more youthful appearance without the risk of puffiness or fluid retention.
PRF = Platelet-Rich Fibrin.
It is made from your own blood and is packed with:
Think of it as a next-gen PRP—more natural, longer-lasting, and better for delicate areas like under the eyes.

At your treatment visit, make sure you are well hydrated. To begin, we will draw 2 vials of blood which is we then place inside a centrifuge. After spinning, the PRF becomes separated from the other blood components and is withdrawn from the top of the vial. While the blood spins, you sit with numbing medication to limit discomfort and the PRF is injected using a blunt-tipped cannula as soon as spinning is complete. The PRF Under Eye injections take about 30 minutes. Because PRF releases growth factors over time, results develop gradually and look very natural. Read this study by Matthias Aust on PRP for the lower eyelid area. It has before and after pictures of its subjects.
⚠️ It does not replace fat loss dramatically like filler, but it improves the skin itself.
Its efficacy depends on patient-specific factors, such as baseline collagen density, skin elasticity, periorbital atrophy, and technical parameters, including centrifugation protocol, injection technique, and dosage. Unlike platelet-rich plasma (PRP), which also harnesses autologous growth factors, PRF offers a sustained release of bioactive components that may enhance collagen production.
Most people need 2–3 sessions, spaced about 4–6 weeks apart.
PRF is very safe, but possible side effects include:
Since it’s autologous (your own blood), allergic reactions are essentially nonexistent.
Great for people who:
Not ideal if:
Each treatment of PRF for the under eye is $350. Expect to need 2-3 treatments every 4-6 weeks for best results. Please read the study on this procedure. Once you begin to see the results of your treatment, yearly maintenance is recommended. Complimentary PRF consultations are at available at the Renaissance Medispa. Our experienced and talented nurse injectors can determine if you are a candidate for the procedure and assess your face for PRF.
Call (920) 233-1540 for your Medispa consultation soon.
Oshkosh, WI (920) 233-1540